

| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 12:39pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 12:39pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 10:15am ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 10:15am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 10:50am ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 10:50am ET |
| Benched | WR | Jauan Jennings SF | Owner | Sat Nov 29 6:20pm ET |
| Started | WR | Troy Franklin DEN | Owner | Sat Nov 29 6:20pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 11:22am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 11:22am ET |
| Started | K | Andres Borregales NE | Owner | Sun Nov 30 5:58am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Fri Nov 28 8:32am ET |
| Started | WR | Ladd McConkey LAC | Owner | Fri Nov 28 8:32am ET |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 8:11pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 12:57am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 12:57am ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 8:32pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 8:32pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 1:36pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 1:36pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 3:40pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 3:40pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 3:40pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 3:40pm ET |
| Benched | RB | Ty Johnson BUF | Owner | Tue Nov 25 3:40pm ET |
| Benched | RB | Kaleb Johnson PIT | Owner | Tue Nov 25 3:40pm ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 27 12:07am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 3:25am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 3:25am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 3:25am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 3:25am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 3:25am ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 12:18pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Tue Nov 25 12:18pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 12:18pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 12:18pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 12:18pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 12:18pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 1:58pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 1:58pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 8:32am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:32am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 4:23pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 4:23pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 4:23pm ET |
| Benched | TE | Dawson Knox BUF | Owner | Wed Nov 26 4:23pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 4:23pm ET |
| Started | WR | Cooper Kupp SEA | Owner | Wed Nov 26 4:23pm ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 4:23pm ET |
| Started | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 4:23pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:29am ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 10:45pm ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 10:45pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:45pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 10:45pm ET |