

| Benched | WR | Zay Flowers BAL | Owner | Fri Dec 5 2:08pm CT |
| Started | WR | D.J. Moore CHI | Owner | Fri Dec 5 2:08pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Dec 2 10:29pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Dec 2 10:29pm CT |
| Started | WR | Michael Wilson ARI | Owner | Fri Dec 5 12:47pm CT |
| Started | QB | Jared Goff DET | Owner | Thu Dec 4 4:22pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Thu Dec 4 4:22pm CT |
| Started | RB | David Montgomery DET | Owner | Thu Dec 4 4:21pm CT |
| Started | QB | Patrick Mahomes KC | Owner | Thu Dec 4 10:20am CT |
| Benched | QB | Jared Goff DET | Owner | Thu Dec 4 10:20am CT |
| Started | QB | Jared Goff DET | Owner | Wed Dec 3 10:01am CT |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Dec 3 10:01am CT |
| Benched | WR | Michael Wilson ARI | Owner | Tue Dec 2 9:22am CT |
| Benched | RB | Christian McCaffrey SF | Owner | Tue Dec 2 9:22am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Dec 2 9:22am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Dec 2 2:27pm CT |
| Started | WR | Drake London ATL | Owner | Tue Dec 2 2:27pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Stefon Diggs NE | Owner | Tue Dec 2 3:16pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Dec 2 3:16pm CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Dec 2 3:16pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Dec 2 3:16pm CT |
| Started | WR | Christian Watson GB | Owner | Tue Dec 2 3:16pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Tue Dec 2 3:16pm CT |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Dec 2 6:53pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Dec 2 6:53pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Dec 2 6:53pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Dec 2 6:53pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Dec 2 1:34pm CT |
| Started | RB | Tyler Allgeier ATL | Owner | Tue Dec 2 1:34pm CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Dec 2 1:33pm CT |
| Started | WR | Malik Washington MIA | Owner | Tue Dec 2 1:33pm CT |
| Benched | RB | TreVeyon Henderson NE | Owner | Thu Dec 4 4:55pm CT |
| Started | WR | Tee Higgins CIN | Owner | Thu Dec 4 4:55pm CT |
| Started | K | Wil Lutz DEN | Owner | Thu Dec 4 10:02am CT |
| Started | D/ST | Baltimore Ravens BAL | Owner | Thu Dec 4 10:02am CT |
| Benched | K | Andres Borregales NE | Owner | Tue Dec 2 11:03pm CT |
| Started | RB | Woody Marks HOU | Owner | Thu Dec 4 5:58pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Thu Dec 4 5:58pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Dec 3 11:40pm CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Dec 3 11:40pm CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Dec 3 11:38pm CT |
| Started | RB | Woody Marks HOU | Owner | Wed Dec 3 10:57am CT |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Dec 3 10:57am CT |
| Started | TE | Tyler Warren IND | Owner | Tue Dec 2 6:29pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Dec 2 6:29pm CT |
| Benched | TE | George Kittle SF | Owner | Tue Dec 2 6:29pm CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Dec 2 6:29pm CT |
| Started | D/ST | Minnesota Vikings MIN | Owner | Thu Dec 4 12:13am CT |
| Benched | QB | Drake Maye NE | Owner | Tue Dec 2 8:53am CT |
| Benched | D/ST | New England Patriots NE | Owner | Tue Dec 2 8:53am CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Dec 2 8:53am CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Dec 3 10:29am CT |
| Started | WR | Luther Burden III CHI | Owner | Wed Dec 3 10:29am CT |