

| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 5:23pm ET |
| Benched | WR | Chris Olave NO | Owner | Tue Oct 28 5:23pm ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 5:23pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 5:23pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Josh Downs IND | Owner | Tue Oct 28 12:04pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Oct 28 12:04pm ET |
| Started | WR | Travis Hunter JAX | Owner | Tue Oct 28 12:04pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Oct 28 12:04pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 12:03pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 12:03pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 2:36pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Oct 28 2:36pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Oct 28 2:36pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Oct 28 2:36pm ET |
| Started | QB | Jordan Love GB | Owner | Tue Oct 28 2:36pm ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 2:36pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 2:36pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Oct 28 2:36pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Oct 28 9:23am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Oct 28 9:23am ET |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 9:23am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Oct 28 9:23am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 9:23am ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Oct 28 9:23am ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Oct 28 10:27am ET |
| Started | D/ST | Houston Texans HOU | Owner | Tue Oct 28 10:27am ET |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 10:27am ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 10:27am ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Oct 28 1:27pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Oct 28 1:27pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 9:31am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 9:31am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Oct 28 1:59pm ET |
| Started | D/ST | Baltimore Ravens BAL | Owner | Tue Oct 28 1:59pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 7:32am ET |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 7:32am ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Tue Oct 28 7:27am ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Oct 28 7:27am ET |
| Benched | WR | Marvin Mims DEN | Owner | Tue Oct 28 7:03am ET |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 7:03am ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 9:47am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 9:47am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 9:47am ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 9:47am ET |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 9:47am ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Oct 28 9:47am ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Oct 28 9:47am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Oct 28 9:47am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 10:00am ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 10:00am ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 10:00am ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Oct 28 10:00am ET |
| Benched | K | Eddy Pineiro SF | Owner | Tue Oct 28 10:00am ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 10:00am ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 10:00am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Oct 28 10:00am ET |