

| Started | D/ST | Houston Texans HOU | Owner | Sat Nov 29 11:14pm ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 25 2:03pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 2:03pm ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 2:02pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 2:02pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 12:36pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 12:36pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:53am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:53am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:53am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:53am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 11:47pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 11:47pm ET |
| Started | K | Matt Prater BUF | Owner | Wed Nov 26 11:46pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:27pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 8:27pm ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 8:27pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 8:27pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 25 8:26pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 8:26pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 12:03pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 12:03pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Thu Nov 27 10:15am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 10:15am ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 10:13am ET |
| Started | QB | Daniel Jones IND | Owner | Thu Nov 27 10:13am ET |
| Started | TE | Taysom Hill NO | Owner | Thu Nov 27 10:13am ET |
| Benched | WR | Romeo Doubs GB | Owner | Thu Nov 27 7:37am ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 7:37am ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 4:50am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 4:50am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 2:50pm ET |
| Benched | TE | Jonnu Smith PIT | Owner | Thu Nov 27 2:50pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 11:50am ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 11:50am ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Tue Nov 25 11:50am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 11:50am ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 7:30am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:30am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 7:30am ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 7:30am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 8:30am ET |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 8:30am ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 26 1:02pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 26 1:02pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:56am ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 8:56am ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Nov 25 8:56am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:56am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Sun Nov 30 4:02am ET |
| Started | TE | Theo Johnson NYG | Owner | Sun Nov 30 4:02am ET |
| Benched | WR | Greg Dortch ARI | Owner | Wed Nov 26 2:30am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 2:30am ET |