

| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 11:12am ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 11:12am ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 11:36pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 11:36pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 11:36pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 11:36pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 10:20am ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:20am ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 10:13am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 10:13am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 11:58am ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:58am ET |
| Benched | K | Daniel Carlson LV | Owner | Thu Nov 27 11:58am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 11:58am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 11:58am ET |
| Started | K | Wil Lutz DEN | Owner | Thu Nov 27 11:58am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Sat Nov 29 5:25pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 5:25pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 2:32pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Sun Nov 30 11:32am ET |
| Benched | TE | Jonnu Smith PIT | Owner | Thu Nov 27 2:08am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 2:08am ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 2:36pm ET |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 25 2:36pm ET |
| Started | WR | Pat Bryant DEN | Owner | Sun Nov 30 12:41pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Sun Nov 30 12:41pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 1:52pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 1:52pm ET |
| Started | WR | Xavier Legette CAR | Owner | Thu Nov 27 1:52pm ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 1:52pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 27 1:52pm ET |
| Benched | K | Andres Borregales NE | Owner | Thu Nov 27 1:52pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 1:52pm ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 1:52pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 7:07am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 6:44pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 6:44pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:44pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:44pm ET |
| Benched | WR | John Metchie III NYJ | Owner | Wed Nov 26 3:46pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 3:46pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 3:46pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 3:46pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 11:07pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 11:07pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 11:07pm ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Tue Nov 25 11:07pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 2:09am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:09am ET |