

| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 8:51am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 8:51am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:51am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 8:51am CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 12:03am CT |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 12:03am CT |
| Benched | RB | Omarion Hampton LAC | Owner | Sat Nov 29 8:25am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 8:25am CT |
| Benched | RB | Michael Carter ARI | Owner | Thu Nov 27 9:23am CT |
| Started | RB | Omarion Hampton LAC | Owner | Thu Nov 27 9:23am CT |
| Started | D/ST | New England Patriots NE | Owner | Sun Nov 30 11:30am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 6:57pm CT |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 6:57pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:57pm CT |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 6:57pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 11:07am CT |
| Benched | WR | Tee Higgins CIN | system | Thu Nov 27 3:38am CT |
| Benched | QB | Daniel Jones IND | Owner | Sun Nov 30 10:41am CT |
| Started | QB | Baker Mayfield TB | Owner | Sun Nov 30 10:41am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 6:34am CT |
| Benched | RB | Ashton Jeanty LV | Owner | Tue Nov 25 2:42pm CT |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 2:42pm CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 2:42pm CT |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 25 2:42pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 2:42pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 2:42pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 8:44pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 8:44pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 8:44pm CT |
| Started | QB | Dak Prescott DAL | Owner | Wed Nov 26 8:44pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:44pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:44pm CT |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 2:47pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 2:47pm CT |
| Started | K | Andres Borregales NE | Owner | Tue Nov 25 2:47pm CT |
| Started | WR | Chris Godwin TB | Owner | Sun Nov 30 11:57am CT |
| Benched | WR | Malik Washington MIA | Owner | Sun Nov 30 11:57am CT |
| Started | WR | John Metchie III NYJ | Owner | Fri Nov 28 10:58am CT |
| Benched | WR | Devaughn Vele NO | Owner | Fri Nov 28 10:58am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 7:54am CT |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 7:54am CT |
| Started | RB | Rachaad White TB | Owner | Tue Nov 25 6:08pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 6:08pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 10:08am CT |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 10:08am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 10:08am CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 10:08am CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 10:08am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Tue Nov 25 10:08am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 10:08am CT |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 10:08am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 1:34pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:34pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 1:33pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:33pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 1:33pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:33pm CT |