

| Benched | QB | Mac Jones SF | Owner | Wed Oct 29 7:55am ET |
| Started | QB | Jared Goff DET | Owner | Wed Oct 29 7:55am ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Wed Oct 29 7:55am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Oct 29 7:55am ET |
| Benched | TE | Tyler Conklin LAC | Owner | Tue Oct 28 10:50am ET |
| Started | TE | Hunter Henry NE | Owner | Tue Oct 28 10:50am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 11:58am ET |
| Benched | WR | Sterling Shepard TB | Owner | Tue Oct 28 11:58am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Oct 28 11:58am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 11:58am ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Oct 28 11:58am ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Oct 28 11:26pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 11:26pm ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Oct 28 11:26pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 11:26pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Oct 28 11:26pm ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Oct 28 11:26pm ET |
| Benched | QB | Bo Nix DEN | Owner | Tue Oct 28 10:28am ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 10:28am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Oct 28 10:28am ET |
| Started | QB | Patrick Mahomes KC | Owner | Tue Oct 28 10:28am ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Oct 28 10:28am ET |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 10:28am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 11:24am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Oct 28 11:24am ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 11:24am ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 11:24am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Oct 28 11:24am ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Oct 28 11:24am ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 9:50am ET |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 9:50am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 9:50am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Oct 28 9:50am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Oct 28 9:50am ET |
| Started | RB | Devin Neal NO | Owner | Tue Oct 28 9:50am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Oct 28 9:50am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 9:50am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 8:45pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Oct 28 8:45pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 8:45pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:45pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 8:45pm ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Oct 28 8:45pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 9:00pm ET |
| Benched | WR | Malik Washington MIA | Owner | Tue Oct 28 9:00pm ET |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 9:00pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 9:00pm ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 9:00pm ET |