

| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 5 3:06pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Nov 5 3:06pm ET |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 5 3:06pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 9:45am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 5 12:29am ET |
| Benched | TE | Tyler Warren IND | Owner | Wed Nov 5 12:29am ET |
| Started | RB | Jordan Mason MIN | Owner | Wed Nov 5 12:29am ET |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Nov 5 12:29am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 12:29pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 12:29pm ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 4 12:29pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 12:29pm ET |
| Started | QB | Jordan Love GB | Owner | Tue Nov 4 12:29pm ET |
| Started | RB | LeQuint Allen JAX | Owner | Tue Nov 4 12:29pm ET |
| Started | RB | Jeremy McNichols WAS | Owner | Tue Nov 4 12:29pm ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 12:29pm ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 11:28am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 11:28am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 4 11:28am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 7:28pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:28pm ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 7:28pm ET |
| Started | RB | J.K. Dobbins DEN | Owner | Tue Nov 4 7:28pm ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 4 7:28pm ET |
| Benched | K | Brandon Aubrey DAL | Owner | Tue Nov 4 7:28pm ET |
| Benched | TE | Evan Engram DEN | Owner | Tue Nov 4 7:28pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 7:28pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 7:28pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 7:28pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 7:28pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 8:50am ET |
| Started | TE | Dalton Schultz HOU | Owner | Tue Nov 4 8:50am ET |
| No starting lineup changes performed this week. |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 1:17pm ET |