

| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:56am ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 9:56am ET |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 25 1:52pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:52pm ET |
| Benched | WR | Parker Washington JAX | Owner | Sun Nov 30 9:30am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 9:30am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Thu Nov 27 9:03am ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 9:03am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 9:03am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 9:03am ET |
| Started | K | Cam Little JAX | Owner | Thu Nov 27 8:28am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 12:12pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 12:12pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 12:12pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:12pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 12:22am ET |
| Started | RB | Brashard Smith KC | Owner | Thu Nov 27 12:22am ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 12:49pm ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 12:49pm ET |
| Benched | TE | Brenton Strange JAX | Owner | Thu Nov 27 8:49am ET |
| Started | RB | Woody Marks HOU | Owner | Thu Nov 27 8:49am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:21pm ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 8:21pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 7:03pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:03pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 10:15am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 10:15am ET |
| Started | TE | Cade Otton TB | Owner | Sat Nov 29 7:16pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 1:27am ET |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 11:50pm ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 26 11:50pm ET |
| Benched | WR | A.J. Brown PHI | Owner | Tue Nov 25 7:00pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 7:00pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 7:00pm ET |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 7:00pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sun Nov 30 11:07am ET |
| Started | WR | Troy Franklin DEN | Owner | Sun Nov 30 11:07am ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 10:19pm ET |
| Benched | WR | Tyrell Shavers BUF | Owner | Wed Nov 26 10:19pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 10:19pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:19pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 10:19pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 10:19pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 10:59pm ET |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Wed Nov 26 10:59pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 10:59pm ET |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 10:59pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 8:18am ET |