

| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 7:08pm CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 7:08pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 7:08pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:08pm CT |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Nov 27 3:29pm CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:29pm CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 4:01pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 4:01pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 1:18pm CT |
| Started | WR | Tetairoa McMillan CAR | Owner | Thu Nov 27 1:18pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Thu Nov 27 7:06am CT |
| Started | QB | Baker Mayfield TB | Owner | Thu Nov 27 7:06am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 7:06am CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 8:23am CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:23am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 8:23am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 8:23am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 2:43pm CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 2:43pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 2:43pm CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 25 2:43pm CT |
| No starting lineup changes performed this week. |
| Benched | TE | Taysom Hill NO | Owner | Thu Nov 27 11:13am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 11:13am CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 7:11pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:11pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 8:03am CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 8:03am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 7:04pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 7:04pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 8:28am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Sun Nov 30 8:28am CT |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 8:05am CT |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 8:05am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 8:05am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 8:05am CT |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 8:05am CT |
| Benched | WR | Jalen Coker CAR | Owner | Thu Nov 27 8:05am CT |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 8:05am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Thu Nov 27 8:05am CT |
| Benched | RB | Blake Corum LAR | Owner | Wed Nov 26 5:28pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 5:28pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Sat Nov 29 8:46pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 8:46pm CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 7:42pm CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 7:42pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 7:42pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 7:42pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 8:53pm CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Wed Nov 26 8:53pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:53pm CT |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 26 8:53pm CT |