

| Benched | RB | Isiah Pacheco KC | Owner | Tue Oct 28 12:42pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Oct 28 12:42pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Oct 28 12:42pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Oct 28 12:42pm ET |
| Benched | QB | Andy Dalton CAR | Owner | Tue Oct 28 7:56pm ET |
| Benched | QB | Spencer Rattler NO | Owner | Tue Oct 28 7:56pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Oct 28 7:56pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 7:56pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 7:56pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 7:56pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 8:29pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Oct 28 8:29pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 8:29pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 8:29pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 8:29pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 8:29pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 8:29pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:29pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Oct 28 5:53pm ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Oct 28 5:53pm ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Oct 28 9:58am ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 9:58am ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Oct 28 9:58am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 9:58am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |