

| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 11:38pm CT |
| Started | TE | Kyle Pitts ATL | Owner | Wed Nov 26 11:38pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 11:21pm CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 11:21pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 6:28pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 6:28pm CT |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 25 6:28pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:28pm CT |
| Started | TE | Gunnar Helm TEN | Owner | Thu Nov 27 11:37am CT |
| Benched | RB | Devin Singletary NYG | Owner | Wed Nov 26 5:42pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 5:42pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 5:42pm CT |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 5:42pm CT |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 8:25am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 8:25am CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Nov 26 12:16pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 12:16pm CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Wed Nov 26 6:20am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 6:20am CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 6:20am CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 6:20am CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 6:28pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 6:28pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:28pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:28pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Jordan Addison MIN | Owner | Fri Nov 28 11:12am CT |
| Started | RB | RJ Harvey DEN | Owner | Fri Nov 28 11:12am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 6:27am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:27am CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 2:27pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:07am CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 7:54am CT |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 7:54am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:54am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:54am CT |
| Benched | QB | Drake Maye NE | Owner | Thu Nov 27 10:42am CT |
| Started | QB | Lamar Jackson BAL | Owner | Thu Nov 27 10:42am CT |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 3:11pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 3:11pm CT |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 25 8:15am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:15am CT |
| Benched | D/ST | Green Bay Packers GB | Owner | Thu Nov 27 10:49am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 10:49am CT |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 10:09pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 26 10:09pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 10:09pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 10:09pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:09pm CT |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 10:09pm CT |