

| Benched | WR | Michael Wilson ARI | Owner | Sat Nov 29 10:09pm CT |
| Started | RB | Breece Hall NYJ | Owner | Sat Nov 29 10:09pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 12:51pm CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Nov 25 12:51pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 12:51pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:51pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 12:51pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 12:51pm CT |
| Benched | QB | Daniel Jones IND | Owner | Sat Nov 29 4:52pm CT |
| Started | QB | Sam Darnold SEA | Owner | Sat Nov 29 4:52pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Thu Nov 27 3:04am CT |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 3:04am CT |
| Benched | WR | Xavier Legette CAR | Owner | Thu Nov 27 3:04am CT |
| Started | QB | Daniel Jones IND | Owner | Thu Nov 27 3:04am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 3:04am CT |
| Started | WR | Tyler Lockett LV | Owner | Thu Nov 27 3:04am CT |
| Benched | WR | Alec Pierce IND | Owner | Sun Nov 30 6:29am CT |
| Benched | TE | Theo Johnson NYG | Owner | Sun Nov 30 6:29am CT |
| Started | QB | Tyrod Taylor NYJ | Owner | Sun Nov 30 6:29am CT |
| Started | TE | Juwan Johnson NO | Owner | Sun Nov 30 6:29am CT |
| Started | WR | Chimere Dike TEN | Owner | Thu Nov 27 6:38pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 6:38pm CT |
| Started | RB | David Montgomery DET | Owner | Thu Nov 27 11:35am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 11:35am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 4:42pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:42pm CT |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 4:42pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 4:42pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 4:42pm CT |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 4:42pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 3:58pm CT |
| Benched | QB | Tyler Shough NO | Owner | Thu Nov 27 3:58pm CT |
| Started | RB | Michael Carter ARI | Owner | Wed Nov 26 5:05pm CT |
| Benched | RB | Trey Benson ARI | Owner | Wed Nov 26 5:05pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 12:29am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 12:29am CT |
| Started | RB | Trey Benson ARI | Owner | Wed Nov 26 12:29am CT |
| Benched | WR | Demario Douglas NE | Owner | Wed Nov 26 12:29am CT |
| Benched | RB | Keaton Mitchell BAL | Owner | Wed Nov 26 12:29am CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 12:29am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 6:11am CT |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 25 6:11am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 4:14pm CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 4:14pm CT |
| No starting lineup changes performed this week. |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 6:55am CT |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 6:55am CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 11:59pm CT |
| Benched | RB | Omarion Hampton LAC | Owner | Wed Nov 26 11:59pm CT |
| Started | RB | Omarion Hampton LAC | Owner | Wed Nov 26 11:59pm CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 11:59pm CT |
| Started | TE | Hunter Henry NE | Owner | Wed Nov 26 8:25pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 26 8:25pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 8:25pm CT |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 8:25pm CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 5:32pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:32pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:32pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:32pm CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 4:48pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 4:48pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 4:48pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 4:48pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 4:48pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 4:48pm CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 8:58am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 8:58am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:40pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 10:40pm CT |