

| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 5:01pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 5:01pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 5:01pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:01pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:01pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:01pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 7:48pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 7:48pm ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 7:48pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 7:48pm ET |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 8:39am ET |
| Benched | WR | Jordan Whittington LAR | Owner | Tue Nov 25 8:39am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 8:39am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:39am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 11:46am ET |
| Started | RB | Tyjae Spears TEN | Owner | Thu Nov 27 11:46am ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 8:12pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 8:12pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 8:12pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:12pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:12pm ET |
| Started | WR | Christian Kirk HOU | Owner | Tue Nov 25 8:12pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 9:34pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 9:34pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 1:03pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 1:03pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:03pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 1:03pm ET |
| Started | WR | D.K. Metcalf PIT | Owner | Sat Nov 29 12:27pm ET |
| Benched | WR | Parker Washington JAX | Owner | Sat Nov 29 12:27pm ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 12:24am ET |
| Benched | TE | Mark Andrews BAL | Owner | Thu Nov 27 12:24am ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 9:42pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:42pm ET |
| Started | RB | Travis Etienne JAX | Owner | Wed Nov 26 9:42pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 9:42pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 9:42pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 9:42pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 8:47am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:47am ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 9:04am ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 9:04am ET |
| Started | RB | Javonte Williams DAL | Owner | Thu Nov 27 9:04am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 9:04am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 2:15pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 2:15pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 2:15pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 2:15pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 8:37am ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Nov 25 8:37am ET |
| Benched | RB | Jahmyr Gibbs DET | Owner | Tue Nov 25 8:37am ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 8:37am ET |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 25 3:10pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Tue Nov 25 3:10pm ET |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 11:34am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 11:34am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 11:34am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 11:34am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 8:37am ET |
| Benched | RB | Devin Singletary NYG | Owner | Thu Nov 27 8:37am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 8:37am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 8:37am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 8:37am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 8:37am ET |