

| Started | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 12:51pm ET |
| Started | K | Will Reichard MIN | Owner | Tue Oct 28 12:51pm ET |
| Started | WR | Christian Watson GB | Owner | Tue Oct 28 12:51pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Oct 28 12:51pm ET |
| Started | QB | Drake Maye NE | Owner | Tue Oct 28 12:51pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 12:51pm ET |
| Benched | K | Will Reichard MIN | Owner | Tue Oct 28 12:51pm ET |
| Benched | WR | Marvin Mims DEN | Owner | Tue Oct 28 12:51pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 12:51pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Oct 28 12:51pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 9:13am ET |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 9:13am ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Oct 28 9:13am ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Oct 28 9:13am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 9:13am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Oct 28 9:13am ET |
| Benched | QB | Carson Wentz MIN | Owner | Tue Oct 28 9:11am ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 9:11am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 8:00am ET |
| Benched | WR | Darius Slayton NYG | Owner | Tue Oct 28 8:00am ET |
| Benched | WR | Kyle Williams NE | Owner | Tue Oct 28 8:00am ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Oct 28 8:00am ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 8:00am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:00am ET |
| Benched | QB | Mac Jones SF | Owner | Tue Oct 28 8:29pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 8:29pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 8:29pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Oct 28 8:29pm ET |
| Started | RB | J.K. Dobbins DEN | Owner | Tue Oct 28 8:29pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 8:29pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tony Pollard TEN | Owner | Tue Oct 28 2:47pm ET |
| Benched | WR | Keon Coleman BUF | Owner | Tue Oct 28 2:47pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 2:47pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 2:47pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 2:46pm ET |
| Started | TE | Pat Freiermuth PIT | Owner | Tue Oct 28 2:46pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Caleb Williams CHI | Owner | Tue Oct 28 11:30pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 11:30pm ET |
| Started | QB | Jordan Love GB | Owner | Tue Oct 28 11:30pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 11:30pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 11:36am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Oct 28 11:36am ET |
| Benched | TE | Jonnu Smith PIT | Owner | Tue Oct 28 11:36am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Oct 28 11:36am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Oct 28 11:36am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Oct 28 11:36am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Devin Neal NO | Owner | Tue Oct 28 7:59pm ET |
| Benched | WR | Rashid Shaheed NO | Owner | Tue Oct 28 7:59pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 7:59pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 7:59pm ET |