

| Started | WR | Marvin Mims DEN | Owner | Fri Oct 24 11:52am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Oct 23 7:33pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Thu Oct 23 7:33pm ET |
| Started | K | Will Reichard MIN | Owner | Thu Oct 23 1:08am ET |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Oct 22 6:06pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Oct 22 6:06pm ET |
| Started | RB | Jordan Mason MIN | Owner | Tue Oct 21 6:29pm ET |
| Benched | K | Jason Myers SEA | Owner | Tue Oct 21 6:29pm ET |
| Benched | WR | Jordan Whittington LAR | Owner | Tue Oct 21 6:29pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 21 6:29pm ET |
| Started | WR | Tee Higgins CIN | Owner | Thu Oct 23 5:03pm ET |
| Benched | WR | Zay Flowers BAL | Owner | Thu Oct 23 5:03pm ET |
| Started | WR | Zay Flowers BAL | Owner | Wed Oct 22 8:49am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Oct 22 8:49am ET |
| Started | QB | Carson Wentz MIN | Owner | Wed Oct 22 8:48am ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Oct 22 8:48am ET |
| Started | QB | Brock Purdy SF | Owner | Wed Oct 22 8:48am ET |
| Benched | QB | Carson Wentz MIN | Owner | Wed Oct 22 8:48am ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Oct 22 8:47am ET |
| Benched | WR | Stefon Diggs NE | Owner | Wed Oct 22 8:47am ET |
| Started | QB | Carson Wentz MIN | Owner | Tue Oct 21 10:57am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Breece Hall NYJ | Owner | Fri Oct 24 8:50pm ET |
| Started | RB | James Cook BUF | Owner | Fri Oct 24 8:50pm ET |
| Started | K | Joey Slye TEN | Owner | Thu Oct 23 4:26pm ET |
| Benched | QB | Dillon Gabriel CLE | Owner | Wed Oct 22 8:47pm ET |
| Benched | WR | Amon-Ra St. Brown DET | Owner | Wed Oct 22 8:47pm ET |
| Started | QB | Josh Allen BUF | Owner | Wed Oct 22 8:47pm ET |
| Started | WR | Darius Slayton NYG | Owner | Wed Oct 22 8:47pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Oct 23 7:46pm ET |
| Benched | WR | Davante Adams LAR | Owner | Tue Oct 21 1:00pm ET |
| Started | RB | Derrick Henry BAL | Owner | Tue Oct 21 1:00pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Thu Oct 23 11:29am ET |
| Started | QB | Joe Flacco CIN | Owner | Thu Oct 23 11:29am ET |
| Benched | RB | Kyren Williams LAR | Owner | Tue Oct 21 5:54pm ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Oct 21 5:54pm ET |
| Benched | RB | Jahmyr Gibbs DET | Owner | Thu Oct 23 5:16pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Thu Oct 23 5:16pm ET |
| Started | RB | Woody Marks HOU | Owner | Thu Oct 23 5:16pm ET |
| Started | TE | Taysom Hill NO | Owner | Thu Oct 23 5:16pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Thu Oct 23 3:35pm ET |
| Benched | QB | Jordan Love GB | Owner | Wed Oct 22 11:04am ET |
| Benched | WR | Nico Collins HOU | Owner | Wed Oct 22 11:04am ET |
| Benched | TE | Sam LaPorta DET | Owner | Wed Oct 22 11:04am ET |
| Started | QB | Caleb Williams CHI | Owner | Wed Oct 22 11:04am ET |
| Started | WR | Jauan Jennings SF | Owner | Wed Oct 22 11:04am ET |
| Started | RB | Aaron Jones MIN | Owner | Wed Oct 22 11:14pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Oct 22 11:14pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Wed Oct 22 11:11pm ET |
| Started | QB | Baker Mayfield TB | Owner | Wed Oct 22 11:11pm ET |
| Benched | RB | RJ Harvey DEN | Owner | Wed Oct 22 11:11pm ET |
| Benched | QB | Michael Penix Jr. ATL | Owner | Wed Oct 22 11:11pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 21 4:20pm ET |
| Benched | D/ST | Seattle Seahawks SEA | Owner | Tue Oct 21 4:20pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Oct 21 4:19pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Oct 21 4:19pm ET |
| Benched | TE | Trey McBride ARI | Owner | Thu Oct 23 6:49pm ET |
| Started | WR | Jordan Addison MIN | Owner | Thu Oct 23 6:49pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Oct 23 6:49pm ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Oct 23 6:49pm ET |
| No starting lineup changes performed this week. |