

| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 10:39am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 10:39am ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 10:39am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 10:39am ET |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 10:39am ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 10:39am ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 3:28pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 3:28pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 3:28pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 3:28pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 3:28pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 25 3:28pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 7:30am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 4:21pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 4:21pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 1:22am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 8:32pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 8:32pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Thu Nov 27 9:46am ET |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 9:46am ET |
| Benched | QB | Kirk Cousins ATL | Owner | Thu Nov 27 9:31am ET |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Thu Nov 27 9:31am ET |
| Benched | K | Jake Elliott PHI | Owner | Thu Nov 27 9:31am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 9:31am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 9:31am ET |
| Started | K | Wil Lutz DEN | Owner | Thu Nov 27 9:31am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Thu Nov 27 12:46pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Thu Nov 27 12:46pm ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 12:46pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 12:46pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Sun Nov 30 12:10am ET |
| Started | WR | Troy Franklin DEN | Owner | Sun Nov 30 12:10am ET |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 10:49am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 10:49am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 10:03am ET |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 10:03am ET |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 2:33am ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 2:33am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 2:33am ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 2:33am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 2:33am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 2:33am ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 2:33am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 2:33am ET |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 12:18pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:18pm ET |