

| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 3:12pm CT |
| Benched | WR | Cooper Kupp SEA | Owner | Tue Nov 25 3:12pm CT |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 3:12pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 3:12pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:12pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 3:12pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Fri Nov 28 11:09am CT |
| Started | QB | Tyler Shough NO | Owner | Fri Nov 28 11:09am CT |
| Benched | QB | Matthew Stafford LAR | Owner | Sat Nov 29 11:22am CT |
| Started | QB | Jaxson Dart NYG | Owner | Sat Nov 29 11:22am CT |
| Benched | TE | Brenton Strange JAX | Owner | Thu Nov 27 3:18pm CT |
| Started | TE | Dalton Schultz HOU | Owner | Thu Nov 27 3:18pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 3:30pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 3:30pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 11:55am CT |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 11:55am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 11:55am CT |
| Started | RB | Keaton Mitchell BAL | Owner | Thu Nov 27 11:55am CT |
| Started | WR | Romeo Doubs GB | Owner | Thu Nov 27 11:55am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 11:55am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 11:26pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 11:26pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:26pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 11:26pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 12:20pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Fri Nov 28 12:20pm CT |
| Started | WR | Parker Washington JAX | Owner | Fri Nov 28 12:17pm CT |
| Benched | WR | Malik Washington MIA | Owner | Fri Nov 28 12:17pm CT |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 12:25pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 12:25pm CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 12:25pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 12:25pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 12:25pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 12:23pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 12:23pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 12:23pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 12:23pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 12:23pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 7:03pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 7:03pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 7:42pm CT |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 7:42pm CT |
| Benched | TE | Ja'Tavion Sanders CAR | Owner | Tue Nov 25 7:42pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:42pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:42pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:42pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:54am CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 6:54am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:54am CT |
| Benched | QB | Aaron Rodgers PIT | Owner | Fri Nov 28 11:33am CT |
| Started | QB | C.J. Stroud HOU | Owner | Fri Nov 28 11:33am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 11:48am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 11:48am CT |
| Started | QB | Aaron Rodgers PIT | Owner | Wed Nov 26 11:48am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:48am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Sat Nov 29 3:21pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Sat Nov 29 3:21pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Fri Nov 28 8:14am CT |
| Started | WR | Jerry Jeudy CLE | Owner | Fri Nov 28 8:14am CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 25 10:58am CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 10:58am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:03am CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 8:03am CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 12:00pm CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:00pm CT |
| Benched | WR | John Metchie III NYJ | Owner | Tue Nov 25 7:05am CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 7:05am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:05am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:05am CT |