

| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 7:37am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 7:37am ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 7:37am ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 7:37am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Oct 28 7:37am ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 10:21am ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 10:21am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Daniel Jones IND | Owner | Tue Oct 28 8:20am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 8:20am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 8:20am ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Oct 28 8:20am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:20am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 8:20am ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Oct 28 3:09pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Oct 28 3:09pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Oct 28 3:09pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Tue Oct 28 3:09pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 3:09pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 3:09pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 3:09pm ET |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 3:09pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Oct 28 3:34pm ET |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 3:34pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 3:34pm ET |
| Started | K | Cam Little JAX | Owner | Tue Oct 28 3:34pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 1:40pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 1:40pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Tue Oct 28 1:40pm ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 1:40pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Oct 28 12:21pm ET |
| Benched | WR | Marvin Mims DEN | Owner | Tue Oct 28 12:21pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 12:21pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 12:21pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Oct 28 5:04pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Oct 28 5:04pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Oct 28 5:03pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 5:03pm ET |
| No starting lineup changes performed this week. |
| Benched | K | Joey Slye TEN | Owner | Tue Oct 28 11:49am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Oct 28 11:49am ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Oct 28 7:55am ET |
| Benched | WR | Kendrick Bourne SF | Owner | Tue Oct 28 7:55am ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 7:55am ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 7:55am ET |
| Started | WR | Tre Tucker LV | Owner | Tue Oct 28 7:55am ET |
| Started | TE | Hunter Henry NE | Owner | Tue Oct 28 7:55am ET |