

| Benched | WR | Tyler Lockett LV | Owner | Fri Nov 28 8:27pm CT |
| Started | WR | Chris Godwin TB | Owner | Fri Nov 28 8:27pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 8:18pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 8:18pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 4:09pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:09pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 6:25am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 6:25am CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 6:25am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 6:25am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 10:13am CT |
| Started | WR | Malik Washington MIA | Owner | Thu Nov 27 10:13am CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 25 7:11pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 7:11pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 11:58am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 11:58am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 25 6:27pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 6:27pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 11:30am CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:30am CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 9:37am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 9:37am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 4:41pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 4:41pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 4:41pm CT |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 4:41pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 4:41pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 4:41pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 4:41pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 4:41pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 4:41pm CT |
| Started | WR | John Metchie III NYJ | Owner | Tue Nov 25 4:41pm CT |
| Started | QB | Bryce Young CAR | Owner | Thu Nov 27 6:34pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 6:34pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:46pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 7:46pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:46pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:46pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 7:46pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 7:46pm CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 7:46pm CT |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 7:46pm CT |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 5:48pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:48pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 5:48pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 5:48pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:48pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 5:48pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:22am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 10:22am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 10:22am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 10:22am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 10:47am CT |
| Started | QB | Jordan Love GB | Owner | Thu Nov 27 10:47am CT |
| Benched | TE | Darnell Washington PIT | Owner | Tue Nov 25 12:09pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 12:09pm CT |