

| Benched | K | Will Reichard MIN | Owner | Thu Nov 27 10:57am ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 27 10:57am ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 3:38pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 3:38pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Tue Nov 25 12:45pm ET |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 12:45pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Sat Nov 29 6:54am ET |
| Started | RB | RJ Harvey DEN | Owner | Sat Nov 29 6:54am ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:59am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 8:59am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 8:59am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:59am ET |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 1:08pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 1:08pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 1:08pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 1:08pm ET |
| Benched | WR | Chris Olave NO | Owner | Sun Nov 30 10:45am ET |
| Started | WR | Michael Wilson ARI | Owner | Sun Nov 30 10:45am ET |
| Benched | WR | Michael Wilson ARI | Owner | Sat Nov 29 7:59am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Sat Nov 29 7:59am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 10:40am ET |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 10:40am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 9:57pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:57pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 9:57pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Wed Nov 26 9:57pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:57pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:57pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:57pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 9:57pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jakobi Meyers JAX | Owner | Sun Nov 30 12:26pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sun Nov 30 12:26pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 7:22pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 7:22pm ET |
| Started | K | Wil Lutz DEN | Owner | Sun Nov 30 10:52am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 8:09am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 11:41pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 11:41pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 10:04am ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 5:52pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 5:52pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 5:52pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 5:52pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 5:52pm ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 5:52pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 11:30pm ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 25 11:30pm ET |