

| Benched | K | Will Reichard MIN | Owner | Thu Nov 27 9:57am CT |
| Started | K | Andres Borregales NE | Owner | Thu Nov 27 9:57am CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 2:38pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 2:38pm CT |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Tue Nov 25 11:45am CT |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 11:45am CT |
| Benched | WR | Jauan Jennings SF | Owner | Sat Nov 29 5:54am CT |
| Started | RB | RJ Harvey DEN | Owner | Sat Nov 29 5:54am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 7:59am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 7:59am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 7:59am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 7:59am CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 12:08pm CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 12:08pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 12:08pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 12:08pm CT |
| Benched | WR | Chris Olave NO | Owner | Sun Nov 30 9:45am CT |
| Started | WR | Michael Wilson ARI | Owner | Sun Nov 30 9:45am CT |
| Benched | WR | Michael Wilson ARI | Owner | Sat Nov 29 6:59am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Sat Nov 29 6:59am CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 9:40am CT |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 9:40am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 8:57pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 8:57pm CT |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 8:57pm CT |
| Benched | TE | Isaiah Likely BAL | Owner | Wed Nov 26 8:57pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:57pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:57pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 8:57pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 8:57pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Jakobi Meyers JAX | Owner | Sun Nov 30 11:26am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sun Nov 30 11:26am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 6:22pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 6:22pm CT |
| Started | K | Wil Lutz DEN | Owner | Sun Nov 30 9:52am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 7:09am CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:41pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:41pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 9:04am CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 4:52pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 4:52pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 4:52pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 4:52pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 4:52pm CT |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 4:52pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 10:30pm CT |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 25 10:30pm CT |