

| Benched | K | Wil Lutz DEN | Owner | Thu Nov 20 12:10am ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 20 12:10am ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 18 5:16pm ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 18 5:16pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 7:14am ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 7:14am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Thu Nov 20 12:56am ET |
| Benched | WR | Jalen Nailor MIN | Owner | Tue Nov 18 9:53am ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Nov 18 9:52am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 18 9:52am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 19 8:46am ET |
| Benched | RB | RJ Harvey DEN | Owner | Wed Nov 19 8:46am ET |
| Started | RB | Emanuel Wilson GB | Owner | Wed Nov 19 8:46am ET |
| Started | WR | Chris Olave NO | Owner | Wed Nov 19 8:46am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 18 3:59pm ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 18 3:59pm ET |
| Started | RB | Keaton Mitchell BAL | Owner | Thu Nov 20 12:31am ET |
| Benched | RB | Jordan Mason MIN | Owner | Thu Nov 20 12:31am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Thu Nov 20 12:31am ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 20 12:31am ET |
| Started | QB | Tyler Shough NO | Owner | Thu Nov 20 12:31am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 20 12:31am ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 18 3:23pm ET |
| Started | RB | Jordan Mason MIN | Owner | Tue Nov 18 3:23pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 3:23pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 3:23pm ET |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 3:23pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 20 5:18am ET |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 18 8:48pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 18 8:48pm ET |
| Benched | D/ST | New York Giants NYG | Owner | Tue Nov 18 8:48pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Nov 18 8:48pm ET |
| Started | TE | Noah Fant CIN | Owner | Tue Nov 18 8:48pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 18 8:57am ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 18 8:57am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 20 9:53am ET |
| Started | RB | Jonathan Taylor IND | Owner | Thu Nov 20 9:53am ET |
| Started | K | Evan McPherson CIN | Owner | Thu Nov 20 9:52am ET |
| Benched | K | Cameron Dicker LAC | Owner | Thu Nov 20 4:17pm ET |
| Started | K | Harrison Butker KC | Owner | Thu Nov 20 4:17pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 5:46pm ET |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 18 5:46pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 18 11:31am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 11:31am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 18 11:31am ET |
| Started | TE | AJ Barner SEA | Owner | Tue Nov 18 11:31am ET |