

| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 6:27am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:27am CT |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 3:57pm CT |
| Started | RB | Woody Marks HOU | Owner | Fri Nov 28 3:57pm CT |
| Benched | RB | Woody Marks HOU | Owner | Fri Nov 28 12:08pm CT |
| Started | RB | Omarion Hampton LAC | Owner | Fri Nov 28 12:08pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 4:05pm CT |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 25 4:05pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 7:49am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:49am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:49am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:49am CT |
| Started | K | Matt Prater BUF | Owner | Sun Nov 30 4:57am CT |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 7:11pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 6:28am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 3:19pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 3:19pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 3:19pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 3:19pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 11:45pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Nov 26 11:45pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:26pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 9:26pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 11:29pm CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 11:29pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 9:37pm CT |
| Benched | QB | Tyler Shough NO | Owner | Wed Nov 26 9:37pm CT |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 6:26pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 6:26pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 6:26pm CT |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 6:26pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 5:13pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 5:13pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:13pm CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 5:13pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 5:13pm CT |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 5:13pm CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 7:08am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 7:49am CT |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 7:49am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Sun Nov 30 11:54am CT |
| Started | QB | Baker Mayfield TB | Owner | Sun Nov 30 11:54am CT |
| Benched | QB | Baker Mayfield TB | Owner | Sun Nov 30 11:53am CT |
| Started | QB | Kirk Cousins ATL | Owner | Sun Nov 30 11:53am CT |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 10:20am CT |
| Started | D/ST | Houston Texans HOU | Owner | Thu Nov 27 10:20am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 11:58pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Nov 26 11:58pm CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 11:57pm CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 2:24pm CT |
| Started | WR | Chimere Dike TEN | Owner | Wed Nov 26 2:24pm CT |
| Benched | QB | Lamar Jackson BAL | Owner | Tue Nov 25 8:44pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 8:44pm CT |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 9:04pm CT |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 9:04pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:04pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:03pm CT |