

| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 2:38am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 2:38am CT |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 2:38am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 2:38am CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 11:01pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 11:01pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 11:01pm CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 11:01pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 12:43pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 12:43pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:43pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 12:43pm CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 11:52am CT |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 11:52am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 11:52am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:52am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 11:52am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 11:52am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:30pm CT |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 25 8:30pm CT |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 8:08am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 8:08am CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 8:08am CT |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 26 8:08am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 8:08am CT |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 8:08am CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Nov 26 9:47pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:47pm CT |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Nov 25 6:23am CT |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 6:23am CT |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Tue Nov 25 5:07pm CT |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 25 5:07pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 5:07pm CT |
| Benched | K | Will Reichard MIN | Owner | Tue Nov 25 5:07pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 5:07pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 5:07pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:38pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:38pm CT |
| Started | K | Harrison Mevis LAR | Owner | Thu Nov 27 9:51am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 9:51am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 8:18pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Wed Nov 26 8:18pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 8:18pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 8:18pm CT |
| Started | TE | Hunter Henry NE | Owner | Wed Nov 26 11:55pm CT |
| Benched | TE | AJ Barner SEA | Owner | Wed Nov 26 11:55pm CT |
| Started | TE | AJ Barner SEA | Owner | Wed Nov 26 10:23am CT |
| Started | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 10:23am CT |
| Started | WR | Justin Jefferson MIN | Owner | Wed Nov 26 10:23am CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:23am CT |
| Started | RB | James Cook BUF | Owner | Wed Nov 26 10:23am CT |
| Started | RB | Chase Brown CIN | Owner | Wed Nov 26 10:23am CT |
| Started | QB | Baker Mayfield TB | Owner | Wed Nov 26 10:23am CT |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 10:09am CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 10:09am CT |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 10:09am CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 10:09am CT |
| Benched | RB | James Cook BUF | Owner | Wed Nov 26 10:09am CT |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 26 10:09am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 10:09am CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 2:57pm CT |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 25 2:57pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 2:51pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:51pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 8:07am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 8:07am CT |
| Started | QB | Jameis Winston NYG | Owner | Tue Nov 25 8:07am CT |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 8:07am CT |