

| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 25 10:43am CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 10:43am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:47pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 7:47pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 7:47pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:47pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 6:20am CT |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 6:20am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 2:48am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 8:30am CT |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 8:30am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:29am CT |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 25 8:29am CT |
| Started | K | Harrison Butker KC | Owner | Wed Nov 26 11:12pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 9:20pm CT |
| Benched | K | Eddy Pineiro SF | Owner | Tue Nov 25 9:20pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:20pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 11:04pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 11:04pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 8:44am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:44am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Thu Nov 27 8:20am CT |
| Started | TE | Taysom Hill NO | Owner | Thu Nov 27 8:20am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 6:55am CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 6:55am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:55am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 6:55am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 3:21pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:21pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Fri Nov 28 11:14pm CT |
| Started | RB | RJ Harvey DEN | Owner | Fri Nov 28 11:14pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 8:44am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:44am CT |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 25 8:44am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:44am CT |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 8:44am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 8:44am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 8:20am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 8:20am CT |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 8:20am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 8:20am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:20am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:20am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 10:00pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 10:00pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 10:00pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 10:00pm CT |