

| Benched | TE | Dalton Schultz HOU | Owner | Sun Nov 30 9:52am ET |
| Started | TE | Darren Waller MIA | Owner | Sun Nov 30 9:52am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 5:02pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 5:02pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:02pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:02pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:02pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 5:02pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Fri Nov 28 8:50pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Fri Nov 28 8:50pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 4:41pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 4:41pm ET |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 4:41pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:41pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 4:41pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 4:41pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 7:49am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 7:49am ET |
| Benched | WR | Demario Douglas NE | Owner | Thu Nov 27 7:49am ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 7:49am ET |
| Benched | QB | Marcus Mariota WAS | Owner | Sat Nov 29 7:40am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Sat Nov 29 7:40am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 8:56am ET |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 26 8:56am ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 5:12pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:12pm ET |
| Benched | RB | Trevor Etienne CAR | Owner | Thu Nov 27 12:52pm ET |
| Started | RB | Jeremy McNichols WAS | Owner | Thu Nov 27 12:52pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 4:29pm ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 4:29pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 4:29pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 4:29pm ET |
| Started | QB | Dillon Gabriel CLE | system | Sun Nov 30 6:23am ET |
| Started | RB | RJ Harvey DEN | system | Sun Nov 30 6:23am ET |
| Benched | RB | Justice Hill BAL | system | Thu Nov 27 6:23am ET |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 10:04am ET |
| Started | WR | Quentin Johnston LAC | Owner | Fri Nov 28 10:04am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 9:58am ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 9:58am ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 8:38am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:38am ET |
| Benched | QB | Geno Smith LV | Owner | Thu Nov 27 11:48am ET |
| Benched | TE | Theo Johnson NYG | Owner | Thu Nov 27 11:48am ET |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 11:48am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 11:48am ET |