

| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:49pm ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 1:46pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 1:46pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 1:46pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:46pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 7:14am ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 7:14am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:14am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:14am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 12:03am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Wed Nov 26 12:03am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 7:17pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:17pm ET |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 25 7:04pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 7:04pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 11:03pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 11:03pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 11:03pm ET |
| Started | WR | Marvin Mims DEN | Owner | Tue Nov 25 11:03pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 7:24pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:24pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |