

| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:29pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Wed Nov 26 10:29pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 10:29pm CT |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 26 10:29pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:49pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 12:46pm CT |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 12:46pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 12:46pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 12:46pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 6:14am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 6:14am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 6:14am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:14am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 5:47pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 5:47pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 11:03pm CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 11:03pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 6:17pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:17pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 12:27am CT |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 25 6:04pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 6:04pm CT |
| Benched | WR | Marvin Mims DEN | Owner | Wed Nov 26 8:45pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 8:45pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:03pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 10:03pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 10:03pm CT |
| Started | WR | Marvin Mims DEN | Owner | Tue Nov 25 10:03pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 6:24pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:24pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 1:20pm CT |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 1:20pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 10:38pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:38pm CT |
| No starting lineup changes performed this week. |