

| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 1:25pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 1:25pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 1:25pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 1:25pm CT |
| Benched | TE | Michael Mayer LV | Owner | Wed Nov 26 9:44pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:44pm CT |
| Benched | WR | Demario Douglas NE | Owner | Wed Nov 26 9:43pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:43pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 9:31am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:31am CT |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 2:01pm CT |
| Started | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 2:01pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 1:46pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 1:46pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:24pm CT |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 7:24pm CT |
| Started | WR | Troy Franklin DEN | Owner | Fri Nov 28 9:31am CT |
| Benched | RB | Devin Neal NO | Owner | Fri Nov 28 9:31am CT |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 27 6:57am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 6:57am CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 11:46am CT |
| Benched | WR | Troy Franklin DEN | Owner | Wed Nov 26 11:46am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 12:22pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 12:22pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:31am CT |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 25 6:31am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 6:31am CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 6:31am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 11:14pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Thu Nov 27 8:37pm CT |
| Started | TE | Kyle Pitts ATL | Owner | Thu Nov 27 8:37pm CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 3:09pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 3:09pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 3:09pm CT |
| Started | WR | John Metchie III NYJ | Owner | Wed Nov 26 3:09pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 10:26pm CT |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 25 10:26pm CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 10:26pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 10:26pm CT |
| Started | K | Tyler Loop BAL | Owner | Tue Nov 25 10:26pm CT |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 10:26pm CT |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 25 10:25pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 10:25pm CT |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 1:14am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 1:14am CT |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 1:13am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 1:13am CT |