

| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 2:39pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Oct 28 2:39pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 2:39pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 2:39pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 2:39pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 2:39pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 11:44pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Oct 28 11:44pm ET |
| Benched | QB | Marcus Mariota WAS | Owner | Tue Oct 28 8:27pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 8:27pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Oct 28 8:27pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Oct 28 8:27pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Tue Oct 28 8:27pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 8:27pm ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 8:27pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Oct 28 8:27pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Oct 28 10:24pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 10:24pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 10:21pm ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Oct 28 10:21pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Oct 28 7:17pm ET |
| Benched | WR | Chris Olave NO | Owner | Tue Oct 28 7:17pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Oct 28 7:17pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Oct 28 7:17pm ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Tue Oct 28 9:40pm ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 9:40pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Oct 28 9:40pm ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 9:40pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jaydon Blue DAL | Owner | Tue Oct 28 7:26am ET |
| Started | RB | David Montgomery DET | Owner | Tue Oct 28 7:26am ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 7:55pm ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 7:55pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 7:55pm ET |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 7:55pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Oct 28 7:55pm ET |
| Started | QB | Andy Dalton CAR | Owner | Tue Oct 28 7:55pm ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Tue Oct 28 7:55pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Oct 28 7:55pm ET |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 7:55pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 8:18am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 8:18am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:18am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:18am ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Oct 28 3:07pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Oct 28 3:07pm ET |
| Benched | WR | Terry McLaurin WAS | Owner | Tue Oct 28 12:10pm ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Oct 28 12:10pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 8:50am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Oct 28 8:50am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Oct 28 8:00am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 8:00am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 8:00am ET |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 8:00am ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 8:00am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 8:00am ET |