

| Started | WR | Marvin Harrison Jr. ARI | Owner | Sat Nov 29 10:51pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 10:51pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:32pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 1:32pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 1:32pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 1:32pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 1:32pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 1:32pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 1:32pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Nov 25 1:32pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 1:26am ET |
| Started | WR | Romeo Doubs GB | Owner | Thu Nov 27 1:26am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 11:41am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 11:41am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 4:18pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 4:18pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 4:18pm ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 4:18pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 10:05pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:05pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Nov 25 10:05pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 10:05pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 4:19pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Wed Nov 26 4:19pm ET |
| Started | RB | Travis Etienne JAX | Owner | Wed Nov 26 4:19pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 4:19pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Calvin Austin III PIT | Owner | Sun Nov 30 12:26am ET |
| Started | WR | Josh Downs IND | Owner | Sun Nov 30 12:26am ET |
| Benched | WR | Josh Downs IND | Owner | Sun Nov 30 12:24am ET |
| Started | WR | Keenan Allen LAC | Owner | Sun Nov 30 12:24am ET |
| Benched | QB | Cam Ward TEN | Owner | Thu Nov 27 3:55pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 3:55pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 12:15am ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 8:46pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Wed Nov 26 8:46pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 1:32pm ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 1:32pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 8:23am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:23am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 10:02am ET |
| Started | RB | Ashton Jeanty LV | Owner | Wed Nov 26 10:02am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Wed Nov 26 10:02am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:02am ET |
| Benched | WR | Matthew Golden GB | Owner | Wed Nov 26 10:01am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:01am ET |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Nov 26 10:01am ET |
| Started | WR | Matthew Golden GB | Owner | Wed Nov 26 10:01am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 3:11pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 3:11pm ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 3:11pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 3:11pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 2:46pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 2:46pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 2:46pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 2:46pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 8:12am ET |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 8:12am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 8:12am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:12am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:12am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:12am ET |