

| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 2:39pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Oct 28 2:39pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 2:39pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 2:39pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 2:39pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 2:39pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Jaydon Blue DAL | Owner | Tue Oct 28 7:26am ET |
| Started | RB | David Montgomery DET | Owner | Tue Oct 28 7:26am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 8:18am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 8:18am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:18am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:18am ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Oct 28 3:07pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Oct 28 3:07pm ET |
| Benched | WR | Terry McLaurin WAS | Owner | Tue Oct 28 12:10pm ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Oct 28 12:10pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 8:50am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Oct 28 8:50am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Oct 28 8:00am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 8:00am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 8:00am ET |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 8:00am ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 8:00am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 8:00am ET |