

| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 10:38am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 10:38am CT |
| Benched | D/ST | Tennessee Titans TEN | Owner | Tue Nov 25 10:38am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 10:38am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 10:38am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 10:38am CT |
| Benched | RB | Blake Corum LAR | Owner | Wed Nov 26 10:02pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 10:02pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 10:02pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 10:02pm CT |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 27 6:32am CT |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 6:32am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:15am CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 9:15am CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:15am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:15am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Khalil Shakir BUF | Owner | Fri Nov 28 5:10pm CT |
| Started | WR | Tetairoa McMillan CAR | Owner | Fri Nov 28 5:10pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 5:38pm CT |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 5:38pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 5:38pm CT |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 25 5:38pm CT |
| Started | K | Andres Borregales NE | Owner | Tue Nov 25 5:38pm CT |
| Started | QB | Max Brosmer MIN | Owner | Sat Nov 29 3:17pm CT |
| Benched | QB | Kirk Cousins ATL | Owner | Sat Nov 29 3:17pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 2:07pm CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 2:07pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 2:06pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 2:06pm CT |
| Started | QB | Kirk Cousins ATL | Owner | Wed Nov 26 2:04pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 2:04pm CT |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 6:54pm CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 6:54pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 8:56am CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 3:06pm CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Nov 26 3:06pm CT |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 3:06pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 3:06pm CT |
| Benched | D/ST | New England Patriots NE | Owner | Wed Nov 26 2:00pm CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 26 2:00pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 6:44pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:44pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 5:34pm CT |
| Benched | WR | Calvin Austin III PIT | Owner | Wed Nov 26 5:34pm CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 5:34pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 5:34pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 5:34pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 5:34pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 4:30pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 4:30pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 4:30pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 4:30pm CT |
| Benched | RB | Sean Tucker TB | Owner | Fri Nov 28 1:07pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Fri Nov 28 1:07pm CT |