

| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 1:28pm CT |
| Started | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 1:28pm CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 1:28pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 1:28pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 8:39am CT |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 8:39am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 7:59am CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 7:59am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 11:18pm CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 11:18pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 3:13pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 3:13pm CT |
| Benched | RB | Jerome Ford CLE | Owner | Thu Nov 27 10:50am CT |
| Benched | WR | Ryan Flournoy DAL | Owner | Thu Nov 27 10:50am CT |
| Benched | K | Harrison Butker KC | Owner | Thu Nov 27 10:50am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 10:50am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 10:50am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 10:50am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 2:49pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 2:49pm CT |
| Benched | QB | Brock Purdy SF | Owner | Thu Nov 27 5:09am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 5:09am CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 7:49am CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 7:49am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:52am CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 7:52am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:52am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:52am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Chuba Hubbard CAR | Owner | Thu Nov 27 2:12pm CT |
| Benched | RB | Kyle Juszczyk SF | Owner | Thu Nov 27 2:12pm CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 2:12pm CT |
| Started | RB | Isiah Pacheco KC | Owner | Thu Nov 27 2:12pm CT |