

| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 1:07pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 1:07pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:07pm ET |
| Benched | WR | Demario Douglas NE | Owner | Tue Nov 25 1:07pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:07pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 1:07pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 1:07pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:07pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 9:10am ET |
| Benched | D/ST | San Francisco 49ers SF | Owner | Wed Nov 26 9:10am ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:10am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 9:10am ET |
| Benched | D/ST | New England Patriots NE | Owner | Wed Nov 26 6:00pm ET |
| Started | D/ST | Detroit Lions DET | Owner | Wed Nov 26 6:00pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jacoby Brissett ARI | Owner | Fri Nov 28 9:51am ET |
| Benched | RB | Ray Davis BUF | Owner | Fri Nov 28 9:51am ET |
| Started | QB | Bo Nix DEN | Owner | Fri Nov 28 9:51am ET |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 9:51am ET |
| Started | K | Harrison Mevis LAR | Owner | Sun Nov 30 5:57am ET |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 8:10pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 7:21am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 7:21am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 7:21am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 4:33pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Fri Nov 28 4:33pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 10:47pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Wed Nov 26 10:47pm ET |
| Benched | RB | Alvin Kamara NO | system | Sun Nov 30 4:36am ET |
| Started | WR | Jauan Jennings SF | system | Sun Nov 30 4:36am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 6:59pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Sat Nov 29 6:59pm ET |
| Started | RB | Devin Neal NO | Owner | Sat Nov 29 11:31am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Sat Nov 29 11:31am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 11:24am ET |
| Benched | RB | Devin Neal NO | Owner | Sat Nov 29 11:24am ET |
| Started | D/ST | Arizona Cardinals ARI | Owner | Thu Nov 27 11:42am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 11:42am ET |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 11:42am ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 11:53am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 11:53am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 11:53am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 11:53am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 8:18am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:18am ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 5:20pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 5:20pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 9:13am ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 9:13am ET |