

| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 12:07pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 12:07pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 12:07pm CT |
| Benched | WR | Demario Douglas NE | Owner | Tue Nov 25 12:07pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 12:07pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 12:07pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:07pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 12:07pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 8:10am CT |
| Benched | D/ST | San Francisco 49ers SF | Owner | Wed Nov 26 8:10am CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 8:10am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:10am CT |
| Benched | D/ST | New England Patriots NE | Owner | Wed Nov 26 5:00pm CT |
| Started | D/ST | Detroit Lions DET | Owner | Wed Nov 26 5:00pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Jacoby Brissett ARI | Owner | Fri Nov 28 8:51am CT |
| Benched | RB | Ray Davis BUF | Owner | Fri Nov 28 8:51am CT |
| Started | QB | Bo Nix DEN | Owner | Fri Nov 28 8:51am CT |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 8:51am CT |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 7:10pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 6:21am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 6:21am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 6:21am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 3:33pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Fri Nov 28 3:33pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 9:47pm CT |
| Started | RB | Omarion Hampton LAC | Owner | Wed Nov 26 9:47pm CT |
| No starting lineup changes performed this week. |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 5:59pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Sat Nov 29 5:59pm CT |
| Started | RB | Devin Neal NO | Owner | Sat Nov 29 10:31am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Sat Nov 29 10:31am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 10:24am CT |
| Benched | RB | Devin Neal NO | Owner | Sat Nov 29 10:24am CT |
| Started | D/ST | Arizona Cardinals ARI | Owner | Thu Nov 27 10:42am CT |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 10:42am CT |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 10:42am CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 10:53am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 10:53am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 10:53am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 10:53am CT |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 7:18am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 7:18am CT |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 4:20pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 4:20pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 8:13am CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 8:13am CT |