

| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 11:35pm ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 11:35pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 11:35pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 11:35pm ET |
| Benched | RB | LeQuint Allen JAX | Owner | Tue Nov 25 1:04pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:04pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 2:18pm ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 2:18pm ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 9:53am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 9:53am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 7:11am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 7:11am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:11am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 7:11am ET |
| Started | WR | Jordan Addison MIN | Owner | Tue Nov 25 7:11am ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 7:11am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 11:58pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 11:58pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 10:12am ET |
| Started | WR | Josh Downs IND | Owner | Thu Nov 27 10:12am ET |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 7:48pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:48pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 7:46pm ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 7:46pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 7:46pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 7:46pm ET |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 8:10pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 4:15pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 4:15pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 3:18pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Nov 25 3:18pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 3:18pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:58am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 8:58am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 8:58am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 8:58am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:58am ET |
| No starting lineup changes performed this week. |
| Started | TE | Darnell Washington PIT | Owner | Tue Nov 25 7:23pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 7:22pm ET |
| Benched | TE | Darnell Washington PIT | Owner | Tue Nov 25 7:22pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:22pm ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 10:08am ET |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 10:08am ET |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 10:08am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:08am ET |