

| Started | RB | Woody Marks HOU | Owner | Sun Dec 14 11:07am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Sun Dec 14 11:07am ET |
| Started | TE | Mike Gesicki CIN | Owner | Sun Dec 14 10:55am ET |
| Benched | TE | Gunnar Helm TEN | Owner | Sun Dec 14 10:55am ET |
| Started | TE | Gunnar Helm TEN | Owner | Fri Dec 12 12:53pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Fri Dec 12 12:53pm ET |
| Started | QB | Brock Purdy SF | Owner | Thu Dec 11 9:33am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Dec 11 9:33am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Tue Dec 9 1:42pm ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Dec 9 1:42pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Dec 9 1:42pm ET |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Tue Dec 9 1:42pm ET |
| Benched | WR | Chris Godwin TB | Owner | Tue Dec 9 1:42pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Dec 9 1:42pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Dec 10 8:11pm ET |
| Benched | TE | Colston Loveland CHI | Owner | Wed Dec 10 8:11pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Wed Dec 10 8:11pm ET |
| Started | TE | George Kittle SF | Owner | Wed Dec 10 8:11pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Denver Broncos DEN | Owner | Sun Dec 14 10:14am ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Sun Dec 14 10:14am ET |
| Benched | TE | Zach Ertz WAS | Owner | Sat Dec 13 2:04am ET |
| Started | TE | Pat Freiermuth PIT | Owner | Sat Dec 13 2:04am ET |
| Benched | WR | Tee Higgins CIN | Owner | Fri Dec 12 12:47pm ET |
| Started | WR | Jordan Addison MIN | Owner | Fri Dec 12 12:47pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Dec 10 8:08am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Sun Dec 14 12:01pm ET |
| Started | WR | Jauan Jennings SF | Owner | Sun Dec 14 12:01pm ET |
| Started | K | Andres Borregales NE | Owner | Sun Dec 14 12:00pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Dec 9 10:42am ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 10:42am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Sun Dec 14 11:40am ET |
| Benched | WR | Pat Bryant DEN | Owner | Sun Dec 14 11:40am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Sun Dec 14 11:40am ET |
| Started | WR | Josh Downs IND | Owner | Sun Dec 14 11:40am ET |
| Benched | TE | Mark Andrews BAL | Owner | Fri Dec 12 8:41pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Fri Dec 12 8:41pm ET |
| Started | D/ST | Chicago Bears CHI | Owner | Thu Dec 11 3:31pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Thu Dec 11 5:42pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Dec 11 5:42pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Dec 10 10:56am ET |
| Started | RB | Tony Pollard TEN | Owner | Wed Dec 10 10:56am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Marquise Brown KC | Owner | Thu Dec 11 5:56am ET |
| Started | WR | Romeo Doubs GB | Owner | Thu Dec 11 5:56am ET |
| Started | WR | Marquise Brown KC | Owner | Tue Dec 9 10:47am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Dec 9 10:45am ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Dec 9 10:45am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Dec 9 10:45am ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Thu Dec 11 8:52am ET |
| Benched | RB | Breece Hall NYJ | Owner | Wed Dec 10 1:05pm ET |
| Started | WR | Nico Collins HOU | Owner | Wed Dec 10 1:05pm ET |