

| Started | RB | Woody Marks HOU | Owner | Sun Dec 14 10:07am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Sun Dec 14 10:07am CT |
| Started | TE | Mike Gesicki CIN | Owner | Sun Dec 14 9:55am CT |
| Benched | TE | Gunnar Helm TEN | Owner | Sun Dec 14 9:55am CT |
| Started | TE | Gunnar Helm TEN | Owner | Fri Dec 12 11:53am CT |
| Benched | TE | Mason Taylor NYJ | Owner | Fri Dec 12 11:53am CT |
| Started | QB | Brock Purdy SF | Owner | Thu Dec 11 8:33am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Dec 11 8:33am CT |
| Started | D/ST | San Francisco 49ers SF | Owner | Tue Dec 9 12:42pm CT |
| Started | WR | Stefon Diggs NE | Owner | Tue Dec 9 12:42pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Dec 9 12:42pm CT |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Tue Dec 9 12:42pm CT |
| Benched | WR | Chris Godwin TB | Owner | Tue Dec 9 12:42pm CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Dec 9 12:42pm CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Dec 10 7:11pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Wed Dec 10 7:11pm CT |
| Started | RB | Christian McCaffrey SF | Owner | Wed Dec 10 7:11pm CT |
| Started | TE | George Kittle SF | Owner | Wed Dec 10 7:11pm CT |
| No starting lineup changes performed this week. |
| Benched | D/ST | Denver Broncos DEN | Owner | Sun Dec 14 9:14am CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Sun Dec 14 9:14am CT |
| Benched | TE | Zach Ertz WAS | Owner | Sat Dec 13 1:04am CT |
| Started | TE | Pat Freiermuth PIT | Owner | Sat Dec 13 1:04am CT |
| Benched | WR | Tee Higgins CIN | Owner | Fri Dec 12 11:47am CT |
| Started | WR | Jordan Addison MIN | Owner | Fri Dec 12 11:47am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Dec 10 7:08am CT |
| Benched | WR | Courtland Sutton DEN | Owner | Sun Dec 14 11:01am CT |
| Started | WR | Jauan Jennings SF | Owner | Sun Dec 14 11:01am CT |
| Started | K | Andres Borregales NE | Owner | Sun Dec 14 11:00am CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Dec 9 9:42am CT |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 9:42am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Sun Dec 14 10:40am CT |
| Benched | WR | Pat Bryant DEN | Owner | Sun Dec 14 10:40am CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Sun Dec 14 10:40am CT |
| Started | WR | Josh Downs IND | Owner | Sun Dec 14 10:40am CT |
| Benched | TE | Mark Andrews BAL | Owner | Fri Dec 12 7:41pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Fri Dec 12 7:41pm CT |
| Started | D/ST | Chicago Bears CHI | Owner | Thu Dec 11 2:31pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Thu Dec 11 4:42pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Dec 11 4:42pm CT |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Dec 10 9:56am CT |
| Started | RB | Tony Pollard TEN | Owner | Wed Dec 10 9:56am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Marquise Brown KC | Owner | Thu Dec 11 4:56am CT |
| Started | WR | Romeo Doubs GB | Owner | Thu Dec 11 4:56am CT |
| Started | WR | Marquise Brown KC | Owner | Tue Dec 9 9:47am CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Dec 9 9:45am CT |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Dec 9 9:45am CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Dec 9 9:45am CT |
| Started | D/ST | Kansas City Chiefs KC | Owner | Thu Dec 11 7:52am CT |
| Benched | RB | Breece Hall NYJ | Owner | Wed Dec 10 12:05pm CT |
| Started | WR | Nico Collins HOU | Owner | Wed Dec 10 12:05pm CT |