

| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 20 11:30am ET |
| Benched | QB | Justin Herbert LAC | Owner | Wed Nov 19 10:04pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 19 10:04pm ET |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 12:24pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 12:24pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 12:24pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Thu Nov 20 4:45pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Thu Nov 20 4:45pm ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 18 9:30am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 9:30am ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 18 9:30am ET |
| Started | TE | Dalton Schultz HOU | Owner | Tue Nov 18 9:30am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 18 7:04pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 18 7:04pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 18 7:04pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 7:04pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 20 8:18am ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Wed Nov 19 1:32pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 19 1:32pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Wed Nov 19 1:32pm ET |
| Started | RB | Alvin Kamara NO | Owner | Wed Nov 19 1:32pm ET |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 19 1:32pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 20 1:54pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Nov 20 1:54pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 20 1:54pm ET |
| Started | WR | Luther Burden III CHI | Owner | Thu Nov 20 1:54pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Devon Achane MIA | Owner | Wed Nov 19 3:11pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 19 3:11pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 19 3:11pm ET |
| Started | WR | Josh Downs IND | Owner | Wed Nov 19 3:11pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 18 8:14pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 8:14pm ET |
| Started | RB | Derrick Henry BAL | Owner | Tue Nov 18 8:14pm ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 18 8:14pm ET |
| No starting lineup changes performed this week. |
| Started | RB | Woody Marks HOU | Owner | Thu Nov 20 9:06am ET |
| Benched | RB | Ashton Jeanty LV | Owner | Thu Nov 20 9:06am ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 20 9:05am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 20 9:05am ET |
| Started | WR | Kayshon Boutte NE | Owner | Tue Nov 18 11:56am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 11:56am ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 11:56am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 18 11:56am ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Nov 18 11:56am ET |
| Benched | TE | Tyler Higbee LAR | Owner | Tue Nov 18 11:56am ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 11:56am ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 18 11:56am ET |
| Benched | K | Cameron Dicker LAC | Owner | Thu Nov 20 4:47pm ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 20 4:47pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 20 4:46pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 18 9:08am ET |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 18 9:08am ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 18 9:08am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 18 9:08am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 18 9:08am ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 18 9:08am ET |