

| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 12:43pm ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 12:43pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:43pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 12:43pm ET |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 26 9:32pm ET |
| Started | QB | Aaron Rodgers PIT | Owner | Wed Nov 26 9:32pm ET |
| Started | WR | George Pickens DAL | Owner | Wed Nov 26 9:32pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 8:17am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 25 8:17am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 8:17am ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 8:17am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:17am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 3:38pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 3:38pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 2:43pm ET |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 2:43pm ET |
| No starting lineup changes performed this week. |
| Started | WR | Ricky Pearsall SF | Owner | Thu Nov 27 12:46pm ET |
| Started | K | Eddy Pineiro SF | Owner | Thu Nov 27 12:46pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 8:08pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 8:08pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 9:59am ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 9:59am ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 9:59am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:59am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:59am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:59am ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 8:06am ET |
| Benched | TE | George Kittle SF | Owner | Tue Nov 25 8:06am ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 8:06am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:06am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 10:15am ET |
| Benched | WR | Tee Higgins CIN | system | Thu Nov 27 4:36am ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 8:36am ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 8:36am ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:35am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 8:35am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 8:35am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:35am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Fri Nov 28 12:41pm ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Fri Nov 28 12:41pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 25 4:30pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 4:30pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 4:26pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 4:26pm ET |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 25 4:26pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 4:26pm ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 9:10am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 9:10am ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 9:10am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 9:10am ET |