

| No starting lineup changes performed this week. |
| Benched | RB | DJ Giddens IND | Owner | Tue Oct 28 6:39pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 6:39pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 6:39pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 6:39pm ET |
| Started | RB | Blake Corum LAR | Owner | Tue Oct 28 6:39pm ET |
| Started | WR | Josh Downs IND | Owner | Tue Oct 28 6:39pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Oct 28 6:39pm ET |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 6:39pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Oct 28 1:56pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 1:56pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 1:55pm ET |
| Started | TE | David Njoku CLE | Owner | Tue Oct 28 1:55pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 6:09pm ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Tue Oct 28 6:09pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Oct 28 6:09pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 6:09pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 6:53pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 6:53pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 6:53pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Oct 28 6:53pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 6:53pm ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Oct 28 6:53pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |