

| Benched | TE | Cade Otton TB | Owner | Sun Nov 30 11:41am CT |
| Started | TE | Taysom Hill NO | Owner | Sun Nov 30 11:41am CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Tue Nov 25 7:33pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 25 7:33pm CT |
| Benched | WR | Troy Franklin DEN | Owner | Thu Nov 27 9:01am CT |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 9:01am CT |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 12:13pm CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 12:13pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 12:13pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 12:13pm CT |
| Benched | WR | Chris Godwin TB | Owner | Wed Nov 26 4:01pm CT |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 4:01pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 11:00am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 11:00am CT |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 11:00am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 11:00am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 11:00am CT |
| Started | WR | Chris Godwin TB | Owner | Tue Nov 25 11:00am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Sun Nov 30 10:57am CT |
| Benched | WR | Deebo Samuel WAS | Owner | Sun Nov 30 10:57am CT |
| Started | TE | Hunter Henry NE | Owner | Sun Nov 30 10:55am CT |
| Benched | TE | Theo Johnson NYG | Owner | Sun Nov 30 10:55am CT |
| Started | TE | Theo Johnson NYG | Owner | Thu Nov 27 10:33am CT |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 10:33am CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 9:39pm CT |
| Benched | K | Joey Slye TEN | Owner | Wed Nov 26 9:39pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 9:38pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:38pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 9:38pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 9:38pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 3:14pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 3:14pm CT |
| Benched | QB | Jordan Love GB | Owner | Thu Nov 27 7:57am CT |
| Benched | K | Chase McLaughlin TB | Owner | Thu Nov 27 7:57am CT |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 7:57am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 7:57am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 7:53am CT |
| Started | RB | Nick Chubb HOU | system | Sun Nov 30 3:36am CT |
| Benched | RB | J.K. Dobbins DEN | system | Sun Nov 30 3:36am CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 12:54pm CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 12:54pm CT |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 25 12:54pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 12:54pm CT |
| Started | D/ST | Houston Texans HOU | Owner | Thu Nov 27 8:38am CT |
| Benched | RB | Devin Singletary NYG | Owner | Wed Nov 26 6:45pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 6:45pm CT |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 26 6:45pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 6:45pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 6:45pm CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 6:45pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 4:54pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 4:54pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 4:53pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 4:53pm CT |
| Benched | RB | Sean Tucker TB | Owner | Sun Nov 30 9:08am CT |
| Benched | WR | Alec Pierce IND | Owner | Sun Nov 30 9:08am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 9:08am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Sun Nov 30 9:08am CT |