

| Benched | WR | Tez Johnson TB | Owner | Sun Nov 30 11:52am CT |
| Started | WR | Chris Godwin TB | Owner | Sun Nov 30 11:52am CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 10:36pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:36pm CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 10:33pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 10:33pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 10:33pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:33pm CT |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 10:33pm CT |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 10:33pm CT |
| Started | K | Cameron Dicker LAC | Owner | Sat Nov 29 8:51pm CT |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 11:38am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 11:38am CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 11:38am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:38am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:38am CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 11:38am CT |
| No starting lineup changes performed this week. |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Sun Nov 30 11:17am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 3:26am CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 4:04pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 4:04pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 4:04pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 4:04pm CT |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 8:47am CT |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 26 8:47am CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 8:47am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 8:47am CT |
| Benched | K | Will Reichard MIN | Owner | Tue Nov 25 4:07pm CT |
| Started | K | Jake Bates DET | Owner | Tue Nov 25 4:07pm CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Nov 25 4:07pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 4:07pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 7:29pm CT |
| Started | D/ST | Buffalo Bills BUF | Owner | Wed Nov 26 7:29pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 7:28pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:28pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 7:28pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 7:28pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Sun Nov 30 3:23am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 3:23am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 11:40am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 27 11:40am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 11:40am CT |
| Started | TE | Dalton Schultz HOU | Owner | Thu Nov 27 11:40am CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 4:06pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 4:06pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 11:49am CT |
| Benched | RB | Trey Benson ARI | Owner | Sun Nov 30 2:38am CT |
| Started | RB | Tyjae Spears TEN | Owner | Sun Nov 30 2:38am CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 1:26am CT |
| Benched | WR | Emeka Egbuka TB | Owner | Wed Nov 26 1:26am CT |
| Started | RB | Trey Benson ARI | Owner | Wed Nov 26 1:26am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 1:26am CT |