

| Benched | QB | Cam Ward TEN | Owner | Fri Nov 28 11:16am CT |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 11:16am CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 3:10pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 3:10pm CT |
| Benched | RB | Omarion Hampton LAC | Owner | Sat Nov 29 5:26pm CT |
| Benched | QB | Lamar Jackson BAL | Owner | Wed Nov 26 9:19pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 9:19pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Wed Nov 26 9:19pm CT |
| Started | RB | Omarion Hampton LAC | Owner | Wed Nov 26 9:19pm CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 9:19pm CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Fri Nov 28 12:56pm CT |
| Started | RB | RJ Harvey DEN | Owner | Fri Nov 28 12:56pm CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 9:53pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:53pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 3:05pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:05pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 6:13am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 6:13am CT |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 25 6:13am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:13am CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Fri Nov 28 5:54pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Fri Nov 28 5:54pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 26 2:36pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 2:36pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 9:27am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:27am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 8:51pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:51pm CT |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 8:51pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 8:51pm CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 11:06am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 11:06am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:06am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 11:06am CT |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 12:31am CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 12:31am CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 7:53pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 7:53pm CT |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 25 7:51pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:51pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:50pm CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 9:50pm CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 9:50pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:50pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 9:50pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:50pm CT |
| No starting lineup changes performed this week. |