

| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 2 11:21am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Dec 2 11:21am ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Dec 2 11:21am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Dec 2 11:21am ET |
| Started | RB | Ty Johnson BUF | Owner | Thu Dec 4 1:30am ET |
| Benched | RB | Tahj Brooks CIN | Owner | Thu Dec 4 1:30am ET |
| Started | TE | AJ Barner SEA | Owner | Wed Dec 3 10:06pm ET |
| Started | WR | Isaac TeSlaa DET | Owner | Wed Dec 3 10:06pm ET |
| Started | RB | Tahj Brooks CIN | Owner | Wed Dec 3 10:06pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Wed Dec 3 10:06pm ET |
| Benched | TE | George Kittle SF | Owner | Wed Dec 3 10:06pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Dec 3 10:06pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Wed Dec 3 10:06pm ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Dec 3 10:06pm ET |
| Benched | RB | Christian McCaffrey SF | Owner | Thu Dec 4 11:50am ET |
| Benched | WR | Stefon Diggs NE | Owner | Thu Dec 4 11:50am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Thu Dec 4 11:50am ET |
| Started | RB | Travis Etienne JAX | Owner | Thu Dec 4 11:50am ET |
| Started | WR | Chris Godwin TB | Owner | Thu Dec 4 11:50am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Dec 4 11:50am ET |
| Started | TE | Darren Waller MIA | Owner | Tue Dec 2 9:33am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Dec 2 9:32am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Dec 2 9:32am ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Dec 2 9:32am ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Dec 2 9:32am ET |
| Started | WR | Calvin Austin III PIT | Owner | Tue Dec 2 9:32am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Kyren Williams LAR | Owner | Thu Dec 4 4:40pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Thu Dec 4 4:40pm ET |
| Benched | RB | Ashton Jeanty LV | Owner | Tue Dec 2 10:33pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Dec 2 10:33pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Dec 2 10:32pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Dec 2 10:32pm ET |
| Benched | RB | Ashton Jeanty LV | Owner | Tue Dec 2 9:24am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Dec 2 9:24am ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Dec 4 6:58pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Thu Dec 4 6:58pm ET |
| Benched | WR | Amon-Ra St. Brown DET | Owner | Thu Dec 4 4:41pm ET |
| Started | WR | Luther Burden III CHI | Owner | Thu Dec 4 4:41pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Dec 4 8:07pm ET |
| Started | QB | Tyler Shough NO | Owner | Thu Dec 4 8:07pm ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Dec 2 7:33am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Dec 2 7:33am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Dec 2 11:05pm ET |
| Started | WR | Tee Higgins CIN | Owner | Tue Dec 2 11:05pm ET |
| No starting lineup changes performed this week. |