

| Benched | RB | Ty Johnson BUF | Owner | Tue Nov 25 9:57pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 9:57pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 9:57pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:57pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 9:57pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:57pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 6:22pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:22pm ET |
| Benched | WR | Tee Higgins CIN | system | Thu Nov 27 6:22am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 5:35pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:35pm ET |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 11:06pm ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 11:06pm ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 11:06pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 11:06pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 6:31pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 6:31pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 6:31pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:31pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 8:04pm ET |
| Started | WR | Malik Washington MIA | Owner | Thu Nov 27 8:04pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 9:46pm ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 9:46pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:46pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 9:46pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:46pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 9:46pm ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 7:15pm ET |
| Benched | WR | Zay Flowers BAL | Owner | Wed Nov 26 7:15pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 7:15pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 7:15pm ET |
| Benched | RB | Trey Benson ARI | Owner | Fri Nov 28 8:45am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 8:45am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:29am ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 9:29am ET |
| Started | RB | Trey Benson ARI | Owner | Wed Nov 26 9:29am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:29am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 2:54pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 2:54pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 2:44pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 2:44pm ET |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 11:12am ET |
| Benched | WR | Christian Watson GB | Owner | Thu Nov 27 11:12am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 11:12am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Thu Nov 27 12:44pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:44pm ET |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 10:12am ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:12am ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 10:12am ET |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 10:12am ET |