

| Benched | WR | Drake London ATL | Owner | Sat Nov 29 8:51pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sat Nov 29 8:51pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 11:21am ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 11:21am ET |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 25 11:21am ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 11:21am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 11:21am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 11:21am ET |
| Benched | WR | Chris Olave NO | Owner | Wed Nov 26 9:19pm ET |
| Started | WR | Justin Jefferson MIN | Owner | Wed Nov 26 9:19pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:45am ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 10:45am ET |
| Started | QB | Jacoby Brissett ARI | Owner | Sun Nov 30 4:47am ET |
| Benched | QB | Brock Purdy SF | Owner | Sun Nov 30 4:47am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 7:32pm ET |
| Benched | K | Andres Borregales NE | Owner | Thu Nov 27 7:32pm ET |
| Started | QB | Brock Purdy SF | Owner | Thu Nov 27 7:31pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 27 7:31pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 8:13am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:13am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:13am ET |
| Started | QB | Caleb Williams CHI | Owner | Tue Nov 25 8:13am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 8:13am ET |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 8:13am ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 8:13am ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:13am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 2:17pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 2:17pm ET |
| Benched | K | Cairo Santos CHI | Owner | Tue Nov 25 9:51am ET |
| Started | K | Wil Lutz DEN | Owner | Tue Nov 25 9:51am ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 11:20am ET |
| Benched | RB | Ray Davis BUF | Owner | Tue Nov 25 11:20am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 11:20am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:20am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 11:20am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:20am ET |
| No starting lineup changes performed this week. |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 1:18am ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 8:18pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:18pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 3:54pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:54pm ET |
| Benched | D/ST | Houston Texans HOU | Owner | Tue Nov 25 11:51pm ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Tue Nov 25 11:51pm ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 11:51pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 11:51pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 8:01am ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 25 8:01am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:01am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 8:01am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 3:58am ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 3:58am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 3:58am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 3:58am ET |