

| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 25 12:07pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 12:07pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 12:07pm CT |
| Started | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 12:07pm CT |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 10:33am CT |
| Benched | WR | Michael Wilson ARI | Owner | Thu Nov 27 10:33am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 10:33am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 10:33am CT |
| Started | D/ST | Atlanta Falcons ATL | system | Sun Nov 30 3:35am CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 3:29pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 3:29pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 6:27pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 6:27pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 6:27pm CT |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 6:27pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 5:41pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 5:41pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 25 5:10pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 5:10pm CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 5:10pm CT |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 25 5:10pm CT |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 27 10:27am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 9:07pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 9:07pm CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 9:07pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 9:07pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 9:07pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 9:07pm CT |
| No starting lineup changes performed this week. |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 27 8:46am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 8:46am CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 10:10pm CT |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 10:10pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 2:42pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 2:42pm CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 2:42pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 2:42pm CT |
| Started | WR | Chris Godwin TB | Owner | Fri Nov 28 11:12pm CT |
| Started | K | Harrison Butker KC | Owner | Wed Nov 26 8:09pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Dylan Sampson CLE | Owner | Wed Nov 26 9:34am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 9:34am CT |
| Benched | WR | Xavier Legette CAR | Owner | Wed Nov 26 9:34am CT |
| Benched | D/ST | Indianapolis Colts IND | Owner | Wed Nov 26 9:34am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 9:34am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 9:34am CT |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 9:34am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 9:34am CT |